Inhaled versus oral steroids for adults with chronic asthmaInhaled corticosteroids form the cornerstone of treatment for most patients with asthma. A range of compounds are available with a wide range of prescribable vermodje steroids reviews. In this overview, we summarize the findings from a number of Cochrane inhaled vs oral steroids for adults with chronic asthma reviews that have examined the relative benefits of different doses of beclometasone dipropionate, budesonide and fluticasone propionate when used to treat children and adults. The key findings are that all inhaled corticosteroids demonstrate a dose—response relationship for efficacy measures, but most of the benefit in mild-to-moderate severity disease is gained in the low-to-moderate dose range of each drug. In this group, high doses of fluticasone lead to small improvements in measures of control at the expense of a steep increase in the incidence of oral side-effects.
Inhaled vs oral steroids for adults with chronic asthma. - PubMed - NCBI
To determine therapeutically equivalent doses of inhaled versus oral steroids for adults with chronic asthma. The Cochrane Airways Group trials register was searched using the terms: Randomised controlled trials were selected of at least 4 weeks duration and included patients over the age of 15 years with chronic asthma. Two independent reviewers screened titles and abstracts from the electronic search, bibliography searches and other contacts. Of these, 10 trials met previously defined inclusion criteria.
Two reviewers independently extracted study characteristics, and outcome measures. All trials were small and no data could be pooled. Carry-over effects were present in at least one cross-over trial. Data from six trials produced the same pattern, in which prednisolone 7. All doses of inhaled steroid appeared to be more effective than alternate day doses of prednisolone up to 60 mg on alternate days. Side-effect data were reported too variably to permit comparisons. A further search was conducted in October which yielded no further trials.
A daily dose of prednisolone 7. Side-effects may be present on low doses, so if there is no alternative to oral steroids, the lowest effective dose should be prescribed. National Center for Biotechnology Information , U.