Hormone therapyHormone steroid ointment for psoriasis hormone replacement therapy menopause wikipedia HRT is any form of hormone therapy wherein the patient, in the course of medical treatment, receives hormoneseither to supplement menopausw lack of naturally occurring hormones or to substitute other hormones for naturally occurring hormones. Common forms of HRT include:. Hormone replacement therapy menopause wikipedia recently aswomen have had a positive attitude towards HRT, but based on the empirical data, these attitudes may be overly optimistic. In the combined hormone trial, the WHI tested only hormonee estrogen Premarin and one progestin Proverain a single pill Premproat a single dose 0. Therefore, the results are not reliable nor representative.
Hormone replacement therapy - Wikipedia
Hormone replacement therapy HRT is any form of hormone therapy wherein the patient, in the course of medical treatment, receives hormones , either to supplement a lack of naturally occurring hormones or to substitute other hormones for naturally occurring hormones. Common forms of HRT include:. As recently as , women have had a positive attitude towards HRT, but based on the empirical data, these attitudes may be overly optimistic.
In the combined hormone trial, the WHI tested only one estrogen Premarin and one progestin Provera , in a single pill Prempro , at a single dose 0. Therefore, the results are not reliable nor representative. To avoid HRT risks, it is essential to use the most effective delivery method of both estrogen and progesterone.
Bioidentical estradiol estrogen when taken orally is converted in the liver to estrone, a weaker bioidentical estrogen. However, when estrogen as estradiol is used transdermally as a patch, gel, or pessary, it enters the bloodstream as bioidentical estradiol.
When estrogen is ingested it is subjected to first pass metabolism Phase I drug metabolism and is processed through the liver. This first pass metabolism stimulates proteins associated with heart disease and stroke, such as C-reactive protein, activated protein C, and clotting factors. Using a patch, gel, or pessary to take estrogen avoids first pass metabolism and the risks associated with it and the same level of blood concentration can be achieved avoiding the serious side effects associated with oral estradiol HRT.
Current research shows that the transdermal route of estradiol administration can also be advantageous for women with diabetes, hypertension and other cardiovascular risk factors, as those risks increase with advancing age. The plant-derived progesterone creams sold over the counter contain too little progesterone to be effective.
Wild yam extract creams are not effective since the natural progesterone present in the extract is not bioavailable. Past research has highlighted potential risks of HRT. The principal results from the Women's Health Initiative Randomized Controlled Trial was that hazard rate of invasive breast cancer exceeded the stopping boundary for this adverse effect and the global index statistic supported risks exceeding benefits.
A study where women going through menopause using HRT with Progestin as a major component of the therapy showed a few adverse effects on hearing, which highlights the importance of choosing bioidentical progesterone instead of synthetic progestin. Not only does the Progestin decrease the functionality of many regions of the ear it also reduces the effectiveness in parts of the central nervous system used for hearing. As caregivers, it is implied that they have more acute stress in their lives and that acute stress along with the HRT is priming negative cardiovascular effects.
However, previous research has shown that the combined type of HRT poses a greater breast cancer risk than tibolone or oestrogen estradiol -only HRT and, because breast cancer is more common than endometrial cancer, the researchers believe that when considering the overall effect of HRT it is important to look at both breast and endometrial cancer.
The Society of Obstetricians and Gynaecologists of Canada recommends Transdermal Estrogen and Micronized Progesterone as a first line hormone therapy option stating that the overall benefits of this therapy include reduction of vasomotor symptoms hot flashes , lower risk of osteoporotic fractures, lessening of urogenital atrophy, lowering somatic pain and arthralgia, lowering the risk of colorectal cancer and mood stabilization. There is a structural difference between hormone therapies that are bioidentical and those that are non-bioidentical, as non-bioidentical are responsible for side effects and health risks in humans.
However, they can have positive health benefits for women, and bioidentical hormones can be customized from individual to individual. HRT has been shown to have other beneficial effects. In a study women taking estrogen through HRT, estrogen was shown to have positive effects on the prefrontal cortex by boosting the working memory. This suggests that estrogen may play a key role in certain frontal lobe functions in women.
These sexual improvements may dissipate after receiving some forms of HRT for extended periods of time. From Wikipedia, the free encyclopedia. This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. September Learn how and when to remove this template message. For the use of estrogens in cancer treatment, see Estrogen therapy oncology. Journal of Advanced Nursing.
Retrieved September 20, The American Medical Association. Retrieved September 21, Society of Obstetricians and Gynaecologists of Canada. Journal of Women's Health. Mary Ann Liebert, Inc. Androstanolone stanolone, dihydrotestosterone, DHT Androstanolone esters Bolazine capronate Drostanolone propionate dromostanolone propionate Epitiostanol Mepitiostane Mesterolone Metenolone acetate methenolone acetate Metenolone enanthate methenolone enanthate Stenbolone acetate Nortestosterone derivatives: Bolandiol dipropionate Nandrolone esters e.
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