Study finds testosterone gels and patches safer than injections | FiercePharma
Additionally I seemed to have lost more weight and developed more lean muscle on the gel. Therefore considering switching back to the gel. Anyone else experienced this? Cooper , May 29, Apr 26, Messages: Check out sub q injections and see if that helps.. Jul 27, Messages: Numbers are not important. How you feel is important.
Gels have an advantage over injections in that gels mimic the natural daily circadian variation of testosterone levels in healthy young men. It seems that this pulsation keeps the body's sensitivity to testosterone higher, so you feel better with lower numbers.
Also, gels tend to give you higher DHT levels, which can make you leaner and increase libido, but can also lead to more hair loss. For me the major disadvantage of gels is the pain of applying them daily, waiting for them to dry, having to schedule your showers around them, and worrying about transfer to others. I just couldn't adhere to the regimen. May 12, Messages: Yes I also felt worse when I switched from gels to injection. To be honest I was put on Nebido long acting and quite possibly I would have seen improvements with time and a better dosing schedule.
If you have to pay then of course gels are not great unless you have deep pockets! However, I feel they are better in many other areas and I just can't quite compute a lot of the complaints - they really don't take long to dry and is does anybody really live such a busy life they can't find an extra 2 minutes to apply them?
Jan 9, Messages: Many do not absorb gels probably due to low thryoid and resulting thickening of skin. I tried compounded and Axiron.
My T levels went down pts on gels. Then tried the pelletes and now on injections. Have no problems with injections. Wolverine99 , May 31, Jan 26, Messages: Sep 2, Messages: The problem I have with gel is inconsitency. I can get a on one test and a on the next. I am also tired of slathering it on every day. Sub Q EOD sounds very appealing. I am just waiting for my script, the doc approved it this week.
Question on prescription size. The pharmacy carries and , what does that mean? BadassBlues , May 31, Apr 2, Messages: Aug 22, Messages: Dec 8, Messages: I do not like any transdermal hormone applications, mainly because they do not work for me. Look up receptor b mentioned there, it accepts androgens and estrogens.
Add to that statins. Statins should come with free crutches. I think testosterone shots are the way to go. JanSz , Jun 3, Mar 24, Messages: Picton , Jun 4, If you want that even feeling like gels give you on shots do your shots E3D subQ some men don't do well on gels it can't get through there skin. Originally Posted by chaos What is your opinion as to the steadiest release from a transdermal. I used them prior to injectibles, but my testosterone never increased, just DHT.
People on the boards told me I didn't absorb since T didn't increase , but my doc said the increase in DHT was proof something absorbed, though he was uncertain as to why all of it seemed to go to DHT. Speaking to your comment, he postulated I absorbed it "in one shot" as opposed to a steady release, so I therefore had a spike in DHT, similar to the spike the day after an IM injection. Ideally, for hormone replacement therapy, the transdermally based hormone is transferred into the fat layer of the skin.
From there, the hormone can be released gradually into the bloodstream, producing stable level. Alcohol-based gels are more useful for hormone replacement since they allow the hormone to be absorbed into the skin fat and to be slowly released into the blood stream. Oil-based transdermal gels or creams - such as the PLO gels - are good for rapidly introducing substances into the system.
They aren't as useful for hormone replacement therapy because they cause the hormone to bypass the skin fat and allow the hormone to directly go into the blood stream.
This causes a large peak and a rapid fall in blood levels. Both alcohol-based and oil-based gels or creams will result in good absorption generally. They generally result in predictable blood levels of hormones and medications. If the blood level does not go up, then it is not being absorbed. Thus if a testosterone transdermal does not result in an appreciable increase in testosterone it is not well absorbed.
Some people will have difficult absorbing a transdermal preparation. For example, people with hypothyroidism, can develop mxedema. This is a thickening of the skin due to the accumulation of mucin - a glue that holds cells together. This prevents transdermal absorption. In my patients, if a person develops lower thyroid hormone levels from either transdermal testosterone or estradiol, testosterone and estradiol levels fall.
When I address thyroid hormone, testosterone and estradiol will again be abssorbed and levels rise. Other reasons for non-absorption include possible ethnic differences or genetic differences in skin such as oilier skin, etc. One other reason a hormone level does not go up is that the dose used is too low. For example, many patients are given one 5 gram packet of Androgel to use. This is too low for many men. Since there is negative feedback controlling testosterone production, at a certain dose, the dose is too low to make up for the loss of one's testicular testosterone production, when exogenous testosterone is added.
Testosterone level actually will decrease when only 1 5-gram pack is used in many men. The percentage of men where testosterone will be low rather than high decreases when two 5-gram packs of Androgel are used. This would be the starting dose I would use. In these men, there is evidence of absorption - such as DHT dihydrotestosterone levels going up. In these men, testosterone in Androgel IS absorbed.
But the dose is too low. Mariano, MD, physician, psychiatrist Any information provided on www. Seek the advice of your physician or other qualified health provider before undertaking any diet, exercise, supplement, medical, or other health program. Jan 23, Messages: Mar 20, Messages: Cooper , Jun 4, You must log in or sign up to reply here. Share This Page Tweet. Your name or email address: Do you already have an account?
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