Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid.The number of non-steroidal anti-inflammatory drugs NSAIDs available for clinical use has dramatically increased during the last decade. As dianabol aromatization general rule, NSAIDs are well absorbed from the gastrointestinal tract, with the exception of clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs and possibly diclofenac, tolfenamic acid and fenbufen which undergoes presystemic hydrolysis clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs form salicylic acid. Concomitant administration of NSAIDs with food or antacids may in some cases lead to delayed or even reduced absorption. The NSAIDs are highly bound to plasma nonstrroidal mainly albuminwhich limits their body distribution to the extracellular spaces. Due to the central role of the liver in the overall elimination of the majority of these compounds, hepatic disease will most likely lead to a significant alteration in their pharmacokinetic behaviour.
Pharmacokinetics of non-steroidal anti-inflammatory drugs - ScienceDirect
The NSAIDs are highly bound to plasma proteins mainly albumin , which limits their body distribution to the extracellular spaces.
Due to the central role of the liver in the overall elimination of the majority of these compounds, hepatic disease will most likely lead to a significant alteration in their pharmacokinetic behaviour. NSAIDs have been reported to be involved in numerous pharmacokinetic drug interactions. Aspirin decreases the plasma concentrations of many other NSAIDs, although the clinical significance of this is uncertain. The most important interactions with NSAIDs are those involving the oral anticoagulants and oral hypoglycaemic agents, though not all NSAIDs have been found to interact with these drugs.
In clinical practice, there appear to be no clear-cut guidelines to assist the clinician in the selection of the most appropriate drug for an individual patient. The selection of an anti-inflammatory drug should be based on clinical experience, patient convenience e.
Since a marked interindividual variability exists in the clinical response to a given NSAID, clinicians prescribing these agents may try several of them sequentially until an adequate response is obtained.
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