Methods of analysis of chiral non-steroidal anti-inflammatory drugs - ScienceDirect
This is a preview of subscription content, log in to check access. The metabolic chiral inversion of 2-arylpropionic acids — a novel route with pharmacological consequences. Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology. Enzymatic inversion at saturated carbon: The stereoselective uptake of ibuprofen enantiomers into adipose tissue. Interrelationships between xenobiotic metabolism and lipid biosynthesis.
Isomeric inversion of ibuprofen R -enantiomer in humans. Stereoselective disposition of ibuprofen enantiomers in man. Pharmacokinetics of ibuprofen enantiomers in man following oral administration of tablets with different absorption rates.
Non-steroidal anti-inflammatory drugs basis for variability in response. Agents and actions Suppl. Pharmacokinetic analysis of the enantiomeric inversion of chiral non-steroidal anti-inflammatory drugs. Pharmacological differences between the optical isomers of ibuprofen: The metabolism of ibuprofen.
Ibuprofen stereoisomer hepatic clearance and distribution in normal and fatty in situ perfused rat liver. Stereoselective inversion of R -fenoprofen to S -fenoprofen in humans. Stereospecific HPLC assay of fenoprofen enantiomers in plasma and urine. Enantioselective disposition of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs.
Pharmacokinetics of the enantiomers of tiaprofenic acid in humans. Antirhematic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics. Pharmacokinetics of tiaprofenic acid enantiomers in renal dysfunction. December 2—7, Honolulu, Hawaii. Pharmacokinetics of ketoprofen enantiomers in healthy subjects following single and multiple doses.
Pharmacokinetics of ketoprofen enantiomers in young and elderly arthritic patients following single and multiple doses. Pharmacokinetics of ketoprofen in the elderly. Pharmacokinetics of ketoprofen in patients with chronic renal failure. Stereoselective pharmacokinetics of ketoprofen in the rat: Stereoselective pharmacokinetics of flurbiprofen in man and rat. Pharmacokinetics of the enantiomers of indoprofen in man.
Stereoselective disposition of indoprofen in surgical patients. Biological activity of indoprofen and its optical isomers. Stereospecific assay and stereospecific disposition of racemic carprofen in rats.
High-performance liquid chromatographic determination of stereoselective disposition of carprofen in humans. Stereoselective analysis of carprofen in plasma by HPLC using precolumn derivatization. Changes in the disposition of carprofen enantiomers caused by probenecid. Separation and determination of naproxen enantiomers in serum by high-performance liquid chromatography.
Stereospecifc inversion of l-CX-methylfluoreneacetic acid of its d-enantiomer in the dog. Inhibition of prostaglandin biosynthesis by clindanac and related compounds: Optical inversion of 2R - to 2S -isomers of 2-[4- 2-oxocyclopentylmefhyl -phenyll-propionic acid loxoprofen , a new anti-inflammatory agent, and its monohydroxy metabolttes in the rat.
Column liquid chromatography for the simultaneous determination of the enantiomers of loxoprofen sodium and its metabolites in human urine.