Pure and Organic CBD & and Hemp Products

Effective medicine provided by mother nature

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Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

This organic product helps cope with:

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Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

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CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

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Pure CBD Freeze

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Pure CBD Lotion

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The truth about buying legal CBD Oil online

Entourage and CBD Effect the Terpenes



  • Entourage and CBD Effect the Terpenes
  • Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
  • Associated Data
  • Cannabis terpenes interact synergistically to create what scientists refer to as an “ entourage effect” that magnifies the therapeutic benefits of the plant's individual. We call this the entourage effect, and it's the reason terpenes have become such a is known as the Entourage Effect; cannabinoids like THC and CBD produce. Terpenes are a large and diverse class of organic molecules that are present in Cannabis and a wide variety of plants.

    Entourage and CBD Effect the Terpenes

    Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. Proceedings 17th Annual Symposium on the Cannabinoids. Radical-scavenging activities of citrus essential oils and their components: J Agric Food Chem. Lea and Blanchard; On the natural history, action, and uses of Indian hemp.

    Red Eye Press; Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress. Sesquiterpene components of volatile oils as skin penetration enhancers for the hydrophilic permeant 5-fluorouracil. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.

    Comparative essential oil compostion of various parts of the turpentine tree Pistacia terebinthus growing wild in Turkey. J Sci Food Agric. Neural basis of anxiolytic effects of cannabidiol CBD in generalized social anxiety disorder: Biosynthesis and catabolism of monoterpenoids. In vitro inhibition of CYP2B1 monooxygenase by beta-myrcene and other monoterpenoid compounds.

    The psychotomimetic effects of intravenous deltatetrahydrocannabinol in healthy individuals: Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol. Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes.

    Delgado P, Moreno F. Antidepressants and the brain. Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Delta 9 -tetrahydrocannabinol. Denson TF, Earleywine M.

    Decreased depression in marijuana users. Determination and characterization of a cannabinoid receptor in rat brain. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Deyo R, Musty R. Proceedings Symposium on the Cannabinoids. A cannabichromene CBC extract alters behavioral despair on the mouse tail suspension test of depression; p. Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptormediated signaling.

    Choice of drugs in the treatment of duodenal ulcer. Crack heads and roots daughters: Chemical composition and antifungal properties of essential oils of three Pistacia species. Effects of Linalool on glutamatergic system in the rat cerebral cortex. Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds.

    Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Activity of cannabis in relation to its delta'-trans-tetrahydro-cannabinol content. Uptake, distribution and elimination of alpha-pinene in man after exposure by inhalation.

    Scand J Work Environ Health. J Toxicol Environ Health. Fan X, Gates RA. Degradation of monoterpenes in orange juice by gamma radiation. Fan X, Sokorai KJ. Changes in volatile compounds of gamma-irradiated fresh cilantro leaves during cold storage. Chemical and biological evaluation of the essential oils of different Melaleuca species. Incorporation experiments with 13 C-labeled glucoses. Metabolic fingerprinting of Cannabis sativa L.

    Analgesic and antiinflammatory activity of constituents of Cannabis sativa L. Franz C, Novak J. Sources of essential oils. Fride E, Russo EB. Schizophrenia, depression, and anxiety.

    The Brain and Body's Marijuana and beyond. Effect of flavour components in lemon essential oil on physical or psychological stress.

    Modulation of effective connectivity during emotional processing by Delta9-tetrahydrocannabinol and cannabidiol. Gaoni Y, Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc. The structure and function of cannabigerol, a new hashish constituent. Cannabichromene, a new active principle in hashish.

    Cannabigerol behaves as a partial agonist at both CB1 and CB2 receptors; p. Emerging roles for endocannabinoids in long-term synaptic plasticity. Metabolic costs of terpenoid accumulation in higher plants. Gershenzon J, Croteau R. Lipid Metabolism in Plants. Anti-inflammatory cannabinoids in diet: Beta-caryophyllene is a dietary cannabinoid. Local anaesthetic activity of the essential oil of Lavandula angustifolia.

    Comparative study of different essential oils of Bupleurum gibraltaricum Lamarck. Preliminary experiments on the chemistry and pharmacology of cannabis. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. The development of Sativex- a natural cannabis-based medicine.

    Cannabidiol and - Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Marijuana withdrawal in humans: Phytotherapeutic uses of essential oils. Effects of oral THC maintenance on smoked marijuana self-administration. Cannabichromene and delta 9-tetrahydrocannabinol: Mono- and sesqui-terpene hydrocarbons of the eseential oil of Cannabis sativa.

    Alkanes of the essential oil of Cannabis sativa. Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression?

    Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats. An endocannabinoid mechanism for stress-induced analgesia. Structure-activity relationships in man of cannabis constituents, and homologs and metabolites of delta9-tetrahydrocannabinol. Headspace volatiles of marijuana.

    Cannabinoid inhibition of adenylate cyclase: Kitab al-Yami' li-mufradat al-adwiya wa-l-agdiya. Neurophysiological and subjective profile of marijuana with varying concentrations of cannabinoids. Central properties and chemcial composition of Ocimum basilicum essential oil.

    Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. Percutaneous absorption of lavender oil from a massage oil. J Soc Cosmet Chem. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: J Pain Symptom Manage. Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Attenuation of allergic contact dermatitis through the endocannabinoid system.

    Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Treatment with lavender aromatherapy in the post-anesthesia care unit reduces opioid requirements of morbidly obese patients undergoing laparoscopic adjustable gastric banding.

    Biological activities of Korean Citrus obovoides and Citrus natsudaidai essential oils against acne-inducing bacteria. Cannabis potency in Europe. Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Effects of citrus fragrance on immune function and depressive states. Chemical composition, antimicrobial and antioxidant activities of the essential oils of Sideritis erythrantha Boiss. Davis endemic in Turkey. Therapeutic use of cannabis by crack addicts in Brazil.

    Lotus Light Publications; Fragrance material review on nerolidol isomer unspecified Food Chem Toxicol. The Illustrated Encyclopedia of Essential Oils: Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. Anti-platelet aggregation and chemical constituents from the rhizome of Gynura japonica. Aromatherapy with essential oils. Antimalarial use of volatile oil from leaves of Virola surinamensis Rol.

    Myrcene mimics the peripheral analgesic activity of lemongrass tea. Universidad de Granada; Fragrance material review on phytol. Ancient Egyptian herbal wines. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. Pathogenicity of Phomopsis ganjae on Cannabis sativa and the fungistatic effect of cannabinoids produced by the host.

    Side effects of pharmaceuticals not elicited by comparable herbal medicines: Altern Ther Health Med. Grotenhermen F, Russo EB, editors. Cannabis and cannabis extracts: Hemp Diseases and Pests: Management and Biological Control.

    Cannabimimetic effects modulated by cholinergic compounds. Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. The essential oil of Cannabis sativa. Symposium on the Cannabinoids. The relevance of the steric factor in the biological activity of CBD derivaties-a tool in identifying novel molecular target for cannabinoids; p.

    The endogenous cannabinoid system controls extinction of aversive memories. Selected oxidized fragrance terpenes are common contact allergens. The breeding of cannabis cultivars for pharmaceutical end uses. Medicinal Uses of Cannabis and Cannabinoids. The inheritance of chemical phenotype in Cannabis sativa L. The pharmacohistory of Cannabis sativa. Cannabinoids As Therapeutic Agents. Mechoulam R, Ben-Shabat S. From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: Mechoulam R, Shvo Y.

    The structure of cannabidiol. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Cannabidiol — recent advances. Mediavilla V, Steinemann S. Essential oil of Cannabis sativa L. J Intl Hemp Assoc. Potency trends of delta 9 -THC and other cannabinoids in confiscated cannabis preparations from to Marihuana, alcohol, and polydrug use: Merzouki A, Mesa JM.

    Concerning kif, a Cannabis sativa L. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism.

    Miyazawa M, Yamafuji C. Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids. Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin. Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis. Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis.

    Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: Identification and characterization of cannabinoids that induce cell death through mitochondrial permeability transition in Cannabis leaf cells.

    Morse K, Mamane D. The Scent of Orange Blossoms: Sephardic Cuisine from Morocco. Ten Speed Press; Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations.

    In vitro acetylcholinesterase inhibitory activity of the essential oil from Acorus calamus and its main constituents. Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. Musty R, Deyo R. A cannabigerol extract alters behavioral despair in an animal model of depression; p. Interactions of deltatetrahydrocannabinol and cannabinol in man. Braude MC, Szara S, editors.

    The Pharmacology of Marihuana. Naqvi NH, Bechara A. The hidden island of addiction: The insula and drug addiction: Damage to the insula disrupts addiction to cigarette smoking. Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease. Repellent activity of essential oils: Effect of deltatetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. Characterization and antimicrobial activity of essential oils of industrial hemp varieties Cannabis sativa L.

    Noma Y, Asakawa Y. Biotransformation of monoterpenoids by microorganisms, insects, and mammals. Psychopharmacology of essential oils. Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR Gas chromatographic-mass spectrometric analysis of volatiles obtained by four different techniques from Salvia rosifolia Sm. Ozturk A, Ozbek H. The anti-inflammatory activity of Eugenia caryophyllata essential oil: Eur J Gen Med.

    The endocannabinoid system as an emerging target of pharmacotherapy. Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats.

    Effect of low doses of Delta 9 -tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats. Psychopharmacol Berl ; Parolaro D, Massi P. Cannabinoids as potential new therapy for the treatment of gliomas. Pauli A, Schilcher H. In vitro antimicrobial activities of essential oils monographed in the European Pharmacopoeia 6th Edition. Involvement of adenosine A1 and A2A receptors in - -linalool-induced antinociception.

    In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes.

    The pharmacology and therapeutic potential of cannabidiol. Kluwer Academic Publishers; The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.

    The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Harvard University Press; Growth and morphology of medicinal cannabis. The propagation, characterisation and optimisation of Cannabis sativa L. PhD, King's College, London, Potency of delta 9-THC and other cannabinoids in cannabis in England in Effects of the essential oil from Citrus aurantium L.

    Cannabinoids as pharmacotherapies for neuropathic pain: Antimicrobial effects of tea-tree oil and its major components on Staphylococcus aureus, Staph. Effect of myrcene on nociception in mice. Linalool modifies the nicotinic receptor-ion channel kinetics at the mouse neuromuscular junction. Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances. Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.

    Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory. Proceedings 19th Annual Symposium on the Cannabinoids. Cannabidiol the non-psychoactive component of cannabis may act as a 5-HT1A auto-receptor agonist to reduce toxin-induced nausea and vomiting; p. Terpenes arrest parasite development and inhibit biosynthesis of isoprenoids in Plasmodium falciparum. Inhalation of vapor from black pepper extract reduces smoking withdrawal symptoms.

    The volatile oil composition of fresh and air-dried buds of Cannabis sativa. Bot J Linn Soc. Handbook of Psychotropic Herbs: The solution to the medicinal cannabis problem. Ethical Issues in Chronic Pain Management. History of cannabis and its preparations in saga, science and sobriquet. A tale of two cannabinoids: Cannabis is more than simply Delta 9 -tetrahydrocannabinol.

    Agonistic properties of cannabidiol at 5-HT-1a receptors. Cannabis, pain, and sleep: Phytochemical and genetic analyses of ancient cannabis from Central Asia. Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia.

    In vitro activity of Citrus bergamia bergamot oil against clinical isolates of dermatophytes. Production of essential oils. Scutt A, Williamson EM.

    Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Cannabinoids act as necrosis-inducing factors in Cannabis sativa. Effects of linalool on glutamate release and uptake in mouse cortical synaptosomes. Chemical profile, antifungal, antiaflatoxigenic and antioxidant activity of Citrus maxima Burm. Osbeck essential oils and their cyclic monoterpene, DL-limonene. Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes.

    The fragrance chemical beta-caryophyllene-air oxidation and skin sensitization. Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors. Antileishmanial activity of a linalool-rich essential oil from Croton cajucara. Stahl E, Kunde R. Die Leitsubstanzen der Haschisch-Suchhunde. Z Gesamte Kriminal Wiss Prax. International Cannabinoid Research Association; The effects of cannabis extracts Tetranabinex and Nabidiolex on human cytochrome Pmediated metabolism; p.

    Biochem Biophys Res Commun. Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. The Lands of the Saracens. Evidence that the plant cannabinoid deltatetrahydrocannabivarin is a cannabinoid CB1 and CB2 antagonist. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.

    Tisserand R, Balacs T. A Guide for Health Care Professionals. Genomic organization of plant terpene synthases and molecular evolutionary implications.

    Composition and enantiomeric analysis of the essential oil of the fruits and the leaves of Pistacia vera from Greece. Constituents of Cannabis sativa L. A review of the natural constituents. Limonene synthase, the enzyme responsible for monoterpene biosynthesis in peppermint, is localized to leucoplasts of oil gland secretory cells. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba Mill. Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice.

    Phase I and pharmacokinetic study of d-limonene in patients with advanced cancer. Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.

    Int J Geriatr Psychiatry. Cannabidivarin, a new hashish constituent] Tetrahedron Lett. Comparison of the subjective effects of delta9-tetrahydrocannabinol and marijuana in humans. Wagner H, Ulrich-Merzenich G. Marihuana, America's New Drug Problem.

    Inhibition of azoxymethane-induced neoplasia of the large bowel by 3-hydroxy-3,7,trimethyl-1,6,dodecatriene nerolidol Carcinogen. Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. Synergy and other interactions in phytomedicines.

    Anti-inflammatory properties of cannabichromene. Proceedings 20th Annual Symposium on the Cannabinoids. Brain cannabinoid CB2 receptors inhibit cocaine self-administration and cocaine-enhanced extracellular dopamine in mice; p. Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis. Antidepressant-like effects of cannabidiol in mice: Cannabidiol as an anxiolytic and antipsychotic. Cannabis contains hundreds of molecules that have the ability to directly interact with our bodies and minds.

    Cannabinoid molecules are relatively unique to the cannabis plant, but other plant-derived molecules such as flavonoids and terpenes also bind to our cells and influence our experiences. Terpenes are a large class of molecules that are produced by many species of plants. The cannabis plant produces at least three dozen different terpenes. The unique scent of each cannabis cultivar strain is a result of the unique balance of terpenes produced by that particular plant.

    Terpenes dissipate into the air very easily, and are the first molecules to vaporize when heat is applied to flower. The flavor of terpenes is maximized by whole-flower vaporization, which gives the brain a chance to interpret the flavor without overwhelming it with the taste of smoke.

    In addition to their aromas, terpenes have direct interactions with our bodies. For instance, alpha-pinene and beta-caryophyllene interfere with molecules that dilate our blood vessels. Less dilation equals less inflammation. Evidence suggests that whole-plant cannabis that includes terpenes is superior to isolated compounds from the plant. This combined benefit is known as the Entourage Effect; cannabinoids like THC and CBD produce better outcomes when they are consumed alongside a supporting cast of terpenes.

    So how is this all happening? What bodily processes or mechanisms could explain why combined terpenes and cannabinoids are superior to isolated ones? Like the example above, one possibility is that cannabinoids and terpenes hit different targets, and the summed activity at those targets receptors or other cellular pathways results in a better outcome; in other words, attacking inflammation at multiple sources of inflammation. On the other hand, we have decent evidence that the undesirable effects of cannabis are minimized when there is a diverse set of molecules consumed at once.

    However, there are a staggering variety of chemical phenotypes chemotypes of cannabis out there in the world. THC may be the conductor, and CBD might be first-chair violin, but every instrument, every different cannabinoid molecule, contributes to the overall experience.

    Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

    Each cannabinoid and terpene has a specific biochemical effect on the You can try a strain that is “high CBD” or “high THC,” but products. Why having other cannabinoids in addition to CBD could be even better. The entourage effect is basically the idea that the cannabis plant contains lots of Terpenes are another group of chemicals found in cannabis. When we think of what is commonly referred to as the entourage effect I think that Much like CBD, the terpene Myrcene (often found in mangos) helps the.

    Associated Data



    Each cannabinoid and terpene has a specific biochemical effect on the You can try a strain that is “high CBD” or “high THC,” but products.


    Why having other cannabinoids in addition to CBD could be even better. The entourage effect is basically the idea that the cannabis plant contains lots of Terpenes are another group of chemicals found in cannabis.


    When we think of what is commonly referred to as the entourage effect I think that Much like CBD, the terpene Myrcene (often found in mangos) helps the.

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