What Is The Endocannabinoid System And How Does It Work? Endocannabinoid System. Scientist first discovered the endocannabinoid system while trying to. The endocannabinoid system plays many crucial roles in your body, and dysregulation or How the System Works and Its Role in Disease. It's known as the Endocannabinoid System, and it is the catalyst behind the many benefits CBD. To understand how CBD works and to fully.
System It Works Endocannabinoid and The How
After several decades of research, scientists studying the effects of marijuana made several important discoveries. Not only did they identify the active ingredient in marijuana, they also discovered where and how it works in the brain—via a new system they called the endocannabinoid EC system.
The EC system—named after the marijuana plant Cannabis sativa and its active ingredient deltatetrahydrocannabinol THC —is a unique communications system in the brain and body that affects many important functions, including how a person feels, moves, and reacts. The natural chemicals produced by the body that interact within the EC system are called cannabinoids, and like THC, they interact with receptors to regulate these important body functions.
Review Figure 1 and the steps below to take a closer look at the components of the EC system, how it works, and the effects of THC. Typically, the chemicals called neurotransmitters are released from a neuron a presynaptic cell , travel across a small gap the synapse , and then attach to specific receptors located on a nearby neuron postsynaptic cell.
This spurs the receiving neuron into action, triggering a set of events that allows the message to be passed along. Then they are released from that cell and travel backward to the presynaptic neuron, where they attach to cannabinoid receptors.
So why is this important? Since cannabinoids act on presynaptic cells, they can control what happens next when these cells are activated. When a person smokes marijuana, THC overwhelms the EC system, quickly attaching to cannabinoid receptors throughout the brain and body. Please note that these are most often side effects associated with chronic consumption of a potent CB1 receptor agonist such as THC, and not with a non-psychoactive substance such as CBD.
CB2 receptors first discovered in occur most commonly in the spleen, tonsils, thymus, and immune cells such as mast cells, monocytes, macrophages, B and T cells, and microglia; only a small number exist in the brain. Changes in CB2 receptor function is synonymous with virtually every type of human disease; be it cardiovascular, gastrointestinal, neurodegenerative, psychiatric, and autoimmune. It even plays a role in liver and kidney function, bone and skin health, cancer, and even pain-related illnesses.
The human body does produce cannabinoids. Endogenous Cannabinoids are neurotransmitters produced within our bodies that bind to cannabinoid receptors in the brain, immune system, and elsewhere. Endocannabinoids perform differently to the more well-known neurotransmitters like serotonin, dopamine, and norepinephrine. Dopamine, for example, is synthesized in advance, stored in the vesicle, and in response to stimuli, is released from the presynaptic cell, where it crosses the synapse, lands on the postsynaptic cell, and causes activation.
Endocannabinoids, on the other hand, are key components of cellular membranes that we manufacture on demand. Since endocannabinoids are hydrophobic, they cannot travel very far in the body and so their effects are localized. Endocannabinoids also travel in the opposite direction to other neurotransmitters. They first leave the postsynaptic cell and end at the presynaptic cell where there are high concentrations of axons. Axons are responsible for the release of traditional neurotransmitters.
This allows the postsynaptic cell to control the flow of neurotransmitters coming from the presynaptic cell. Instead, many of the therapeutic benefits of CBD are created through indirect actions. These receptors are involved in regulating pain, body temperature, and inflammation. This inhibition creates higher levels of endocannabinoids like anandamide.
It also performs other important functions like regulating feeding behaviors and assisting with embryo implantation during the early stages of pregnancy. For example, the medical community has already identified that THC can be an effective treatment for multiple ailments, including the side effects of chemotherapy. Because CBD inhibits the negative effects of THC, there is a possibility that administering the two together could be more beneficial than supplementing with THC alone.
Because CBD stimulates the endocannabinoid system, it helps to promote homeostasis in the body, reducing the sensation of pain and inhibiting inflammation. Research into the possible uses of CBD and other cannabis compounds is a growing area of study, meaning the list of potential benefits is likely to grow. Your email address will not be published. What is CBD Oil?
The Science of the Endocannabinoid System: How THC Affects the Brain and the Body
The Science of the Endocannabinoid System: How THC Affects the Brain works in the brain—via a new system they called the endocannabinoid (EC) system. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, .. It is thought that hypothalamic neurons tonically produce endocannabinoids that work to tightly regulate hunger. The amount of endocannabinoids. How the science of the endocannabinoid system explains why hemp oil, and other cannabis-based therapies actually work.